TNFR2 抗体-抗体-抗体-生物在线
TNFR2 抗体

TNFR2 抗体

商家询价

产品名称： TNFR2 抗体

英文名称： TNFR2 Antibody

产品编号： XY19272-1-

产品价格： null

产品产地： 中国/美国

品牌商标： XYbscience

更新时间： 2023-08-17T09:55:27

使用范围： WB,ELISA,IHC-P,IHC-F,IF

上海信裕生物科技有限公司
  • 联系人 : 徐经理
  • 地址 : 上海市闵行莘庄工业区春东路508号A1-2F
  • 邮编 : 200612
  • 所在区域 : 上海
  • 电话 : 152****8802
  • 传真 : 021-37680378
  • 邮箱 : shxysw02@163.com
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 TNFR2 抗体Applications

In-house applications ELISA, WB, IHC, IF, FC, IP     Application not tested? Please see our Guarantee.
Published applications IF Publications 1 citations –view here
Species specificity Human, Mouse; other species not tested.
Published Species Mouse
Images
Prev12NextView more validation data
  • 19272-1-AP;Jurkat cellsJurkat cells were subjected to SDS PAGE followed by western blot with 19272-1-AP(TNFR2 antibody) at dilution of 1:500
  • 19272-1-AP;HeLa cells1X10^6 HeLa cells were stained with 0.5ug TNFR2 antibody (19272-1-AP, red) and control antibody (blue). Fixed with 4% PFA blocked with 3% BSA (30 min). FITC-Goat anti-Rabbit IgG with dilution 1:100.
  • 19272-1-AP;human spleen tissueImmunohistochemical of paraffin-embedded human spleen using 19272-1-AP(TNFR2 antibody) at dilution of 1:50 (under 10x lens)
  • 19272-1-AP;human spleen tissueImmunohistochemical of paraffin-embedded human spleen using 19272-1-AP(TNFR2 antibody) at dilution of 1:50 (under 40x lens)
  • 19272-1-AP;Hela cellsImmunofluorescent analysis of Hela cells, using TNFRSF1B antibody 19272-1-AP at 1:25 dilution and Rhodamine-labeled goat anti-rabbit IgG (red).
  • 19272-1-AP;HEK-293 cellsIP Result of anti-TNFR2 (IP:19272-1-AP, 4ug; Detection:19272-1-AP 1:500) with HEK-293 cells lysate 1200ug.
Positive WB detected in Jurkat cells, HEK-293 cells, MCF7 cells, mouse thymus tissue
Positive IP detected in HEK-293 cells
Positive IHC detected in Human spleen tissue
Positive IF detected in Hela cells
Positive FC detected in HeLa cells
Recommended dilution WB : 1:200-1:2000
IP : 1:200-1:2000
IHC : 1:50-1:200
IF : 1:10-1:100
 TNFR2 抗体Application key: WB = Western blotting, IHC = Immunohistochemistry, IF = Immunofluorescence,
IP = Immunoprecipitation
Product Information
Source Rabbit Purification method Antigen affinity purification
Isotype IgG Storage PBS with 0.02% sodium azide and 50% glycerol pH 7.3. Store at -20oC.
Immunogen Information TNFR2 抗体
Immunogen TNFR2 fusion protein ag5866 Full name Tumor necrosis factor receptor superfamily, member 1B
Calculated molecular
weight		 48 kDa Observed molecular 
weight		 75 kDa
GenBank accession 
number		 BC052977 Gene ID (NCBI) 7133
Gene symbol TNFRSF1B Synonyms CD120b, Etanercept, p75, p75TNFR, p80 TNF alpha receptor, TBP 2, TBPII, TNF R II, TNF R2, TNF R75, TNF Receptor 2, TNF Receptor II, TNF RII, TNFBR, TNFR II, TNFR1B, TNFR2, TNFR80, TNFRSF1B
Background

Tumor necrosis factor-alpha (TNFA/TNFSF2) is amultifunctional cytokine that plays a key role in regulating inflammation, immune functions, host defense, and apoptosis (PMID: 16407280). TNFA signals through two distinct cell surface receptors, TNFR1 (TNFRSF1A, CD120a, p55) and TNFR2 (TNFRSF1B, CD120b, p75). TNFR1 is widely expressed, whereas TNFR2 exhibits more restricted expression, being found on CD4 and CD8 T lymphocytes, endothelial cells, microglia, oligodendrocytes, neuron subtypes, cardiac myocytes, thymocytes and human mesenchymal stem cells (PMID: 20489699; 22374304). In contrast to TNFR1, TNFR2 does not have a death domain. TNFR2 only signals for antiapoptotic reactions. However, recent evidence indicates that TNFR2 also signals to induce TRAF2 degradation (PMID: 22374304). Various defects in the TNFR2 pathway, due to polymorphisms in the TNFR2 gene, upregulated expression of TNFR2 and TNFR2 shedding, have been implicated in the pathology of several autoimmune disorders (PMID: 20489699). TNFR2 抗体

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